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Synaptic hYdration-governed proteiN Assessment of Protein Toxicity and carbonyl reActivity

SYNAPTA investigates how the molecular architecture and hydration dynamics of reactive carbonyls govern biological stability, neural integrity, and toxicological response. By integrating molecular simulation with targeted synthesis and kinetic validation, the project seeks to reveal how solvation order and electrophilic reactivity manifest as quantifiable biological effects. Through a deeply interdisciplinary framework—bridging computational chemistry, organic chemistry, neurology, and toxicology—SYNAPTA advances predictive toxicology and next-generation neuroprotective science.